Femring® brand estradiol vaginal ring is also used to treat hot flushes ('hot flashes' sudden strong feelings of heat and sweating) in women who are experiencing menopause. Premarin (vaginal estrogen) is used to treat vaginal dryness, itching, and burning painful or difficult urination and sudden need to urinate immediately in women who are experiencing or have experienced menopause (change of life the end of monthly menstrual periods).